Altered blood pressure progression in the community and its relation to clinical events.
Ingelsson E, Gona P, Larson MG, Lloyd-Jones DM, Kannel WB, Vasan RS, Levy D.Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702-5803, USA.BACKGROUND: Long-term blood pressure (BP) progression and its importance as a predictor of clinical outcome have not been well characterized across different periods. METHODS: We evaluated period trends for 3 BP variables (long-term slope and mean BP during a baseline period of 16 years, and last baseline value) in an earlier period (1953-1971; n = 1644, mean participant age, 61 years) and in a later period (1971-1990; n = 1040, mean participant age, 58 years) in participants in the Framingham Heart Study who initially did not have hypertension. In addition, we explored the relation of BP to cardiovascular disease incidence and all-cause mortality in the 2 periods, each with up to 16 years of follow-up. RESULTS: Long-term slope, mean, and last baseline BP measurements were significantly lower in the later period (P < .001). Rates of hypertension control (BP <140/90 p =" .03;" p =" .04).">